Biosynthesis: A terminal triple bond toolbox

December 22nd, 2014 by Victoria S Haritos

Nature Chemical Biology 11, 98 (2015). doi:10.1038/nchembio.1731

Author: Victoria S Haritos

Terminal triple bonds feature in natural products, but their biosynthesis is little known. Now a terminal acetylenase has been characterized for substrate specificity for the first time, and an application to 'bio-click' chemistry has been shown by incorporation of the moiety into natural product scaffolds.