Freedom of movement

January 21st, 2019 by Ulrich Rass

Freedom of movement

Freedom of movement, Published online: 21 January 2019; doi:10.1038/s41589-019-0224-7

Holliday junction resolvases lock dynamic DNA four-way junctions into specific structural conformations for symmetric DNA cleavage. Single-molecule studies now reveal that resolvases can relax their grip, enabling Holliday junction conformer transitions and branch migration in the enzyme-bound form.