Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15

November 4th, 2019 by Tyler B. Faust

Nature Chemical Biology, Published online: 04 November 2019; doi:10.1038/s41589-019-0378-3

Cryo-EM and crystal structural analysis of DDB1–DCAF15–DDA1 in complex with E7820 and RBM39 reveal that aryl-sulfonamides reshape the surface of the cullin RING ligase substrate receptor DCAF15 to bind and degrade the splicing factor RBM39.
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