p63 is a cereblon substrate involved in thalidomide teratogenicity

October 7th, 2019 by Tomoko Asatsuma-Okumura

Nature Chemical Biology, Published online: 07 October 2019; doi:10.1038/s41589-019-0366-7

Zebrafish p63 isoforms were identified as thalidomide-dependent neosubstrates of the cereblon-containing E3 ligase complex. ∆Np63α and TAp63α are responsible for thalidomide-induced malformations of pectoral fins and otic vesicles, respectively.