Designing a chemical inhibitor for the AAA protein spastin using active site mutations

February 18th, 2019 by Tommaso Cupido

Designing a chemical inhibitor for the AAA protein spastin using active site mutations

Designing a chemical inhibitor for the AAA protein spastin using active site mutations, Published online: 18 February 2019; doi:10.1038/s41589-019-0225-6

The AAA protein spastin is needed for cell division and organelle transport. Testing spastin constructs with engineered mutations resulted in the identification of a chemical probe to analyze spastin-specific functions in cells.
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