Continuous directed evolution of proteins with improved soluble expression

August 20th, 2018 by Tina Wang

Continuous directed evolution of proteins with improved soluble expression

Continuous directed evolution of proteins with improved soluble expression, Published online: 20 August 2018; doi:10.1038/s41589-018-0121-5

Through use of a split-intein pIII, soluble expression phage-assisted continuous evolution (SE-PACE) enables two simultaneous positive selections to rapidly evolve proteins with improved expression while maintaining their desired activities.
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