Design of fast proteolysis-based signaling and logic circuits in mammalian cells

December 10th, 2018 by Tina Fink

Design of fast proteolysis-based signaling and logic circuits in mammalian cells

Design of fast proteolysis-based signaling and logic circuits in mammalian cells, Published online: 10 December 2018; doi:10.1038/s41589-018-0181-6

Protease-cleavable orthogonal-coiled-coil-based (SPOC) systems, in which split viral proteases are activated by small molecules and cleave coiled-coil protease substrates, reprogram signaling with rapid kinetics in mammalian cells.
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