Reprogramming fatty acyl specificity of lipid kinases via C1 domain engineering

January 13th, 2020 by Timothy B. Ware

Nature Chemical Biology, Published online: 13 January 2020; doi:10.1038/s41589-019-0445-9

A chemoproteomics and protein engineering strategy to investigate metabolic activity of lipid kinases led to assignment of a key role for atypical C1 domains in directing fatty acyl specificity of diacylglycerol kinase function in live cells.
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