Small-molecule allosteric inhibitors of BAX

February 4th, 2019 by Thomas P. Garner

Small-molecule allosteric inhibitors of BAX

Small-molecule allosteric inhibitors of BAX, Published online: 04 February 2019; doi:10.1038/s41589-018-0223-0

Using biochemical and NMR studies, a class of small-molecule inhibitors termed BAX activation inhibitors were found to bind directly to a previously unrecognized pocket of inactive BAX and allosterically inhibit conformational changes in BAX.