Nuclear receptors: PPARα ligands make memories

November 15th, 2016 by Thomas P Burris

Nature Chemical Biology 12, 993 (2016). doi:10.1038/nchembio.2241

Author: Thomas P Burris

Three newly identified endogenous ligands of the nuclear receptor PPARα—hydroxydimethylbutyrate, hexadecanamide and octadecenamide—are implicated in the noncanonical activity of PPARα in synaptic function and hippocampal plasticity.