mRNA structure determines modification by pseudouridine synthase 1

September 2nd, 2019 by Thomas M. Carlile

Nature Chemical Biology, Published online: 02 September 2019; doi:10.1038/s41589-019-0353-z

An in vitro method was developed to screen mRNA sites for psedouridine modification by specific pseudouridylating enzymes and identify an RNA structural motif for Pus1, which can be used to predict new pseudouridylated mRNA targets in vivo.