Transcriptional kinases: Less is more (or less)

December 17th, 2015 by Thomas G Boyer

Nature Chemical Biology 12, 4 (2016). doi:10.1038/nchembio.1985

Author: Thomas G Boyer

Two new studies describe potent and selective inhibitors of CDK8/CDK19. Application of these high-quality probes to several cancer models provides new mechanistic insight and reveals functional dichotomy with respect to Mediator kinases in signal-dependent gene regulation, with important implications for targeted cancer therapy.