Flipping out the peptide

September 17th, 2018 by Stephanie Gras

Flipping out the peptide

Flipping out the peptide, Published online: 17 September 2018; doi:10.1038/s41589-018-0133-1

T cell cross-reactivity enables the immune system to recognize a large array of peptides. A new study shows that T cells can achieve cross-recognition by using the remarkable plasticity of peptides, through flipping the peptide out of the binding cleft.