A masked zinger to block GPX4

March 30th, 2020 by Stefan G. Kathman

Nature Chemical Biology, Published online: 30 March 2020; doi:10.1038/s41589-020-0511-3

Ferroptosis induced by GPX4 inhibition offers promise for killing drug-resistant cancer cells, yet current GPX4 inhibitors lack selectivity. The discovery of masked nitrile oxide electrophiles as selective prodrug inhibitors of GPX4 points to an attractive path for chemically inducing ferroptosis.