PGE1 and PGA1 bind to Nurr1 and activate its transcriptional function

May 25th, 2020 by Sreekanth Rajan

Nature Chemical Biology, Published online: 25 May 2020; doi:10.1038/s41589-020-0553-6

Prostaglandins PGE1 and PGA1 have neuroprotective effects by enhancing the transcriptional activity of Nurr1 by directly binding to its ligand-binding domain and upregulating their target genes implicated in Parkinson’s disease.
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