Antibiotic resistance: Blocking tetracycline destruction

May 8th, 2017 by Sonja Petkovic

Nature Chemical Biology 13, 694 (2017). doi:10.1038/nchembio.2396

Authors: Sonja Petkovic & Winfried Hinrichs

Enzymology and structural and functional characterization of some FAD-dependent monooxygenases provide insights into degradation of tetracycline antibiotics, but also show unexpected features of substrate recognition, reaction mechanism, and competitive inhibition.