Isoform-selective regulation of mammalian cryptochromes

March 30th, 2020 by Simon Miller

Nature Chemical Biology, Published online: 30 March 2020; doi:10.1038/s41589-020-0505-1

Cell-based phenotypic screening of small-molecule circadian clock modulators identified isoform-selective compounds for highly homologous clock proteins CRY1 and CRY2, revealing a key role of the disordered C-terminal region in compound selectivity.