Structural equilibrium underlying ligand-dependent activation of β<sub>2</sub>-adrenoreceptor

January 20th, 2020 by Shunsuke Imai

Nature Chemical Biology, Published online: 20 January 2020; doi:10.1038/s41589-019-0457-5

NMR structural analysis of an active state of the β2-adrenergic receptor defines a unique orientation for the intracellular half of TM6, responsible for G-protein binding, including an equilibrium among three conformations of a key microswitch.
  • Posted in Nat Chem Biol, Publications
  • Comments Off on Structural equilibrium underlying ligand-dependent activation of β<sub>2</sub>-adrenoreceptor