Defining new chemical space for drug penetration into Gram-negative bacteria

November 16th, 2020 by Shibin Zhao

Nature Chemical Biology, Published online: 16 November 2020; doi:10.1038/s41589-020-00674-6

The difficulty of antibiotic discovery posed by the double-membrane cell envelope of Gram-negative bacteria and active drug efflux requires better understanding of bacterial permeability and compound accumulation, and more diverse chemical libraries.
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