Rewiring bacterial two-component systems by modular DNA-binding domain swapping

May 20th, 2019 by Sebastian R. Schmidl

Nature Chemical Biology, Published online: 20 May 2019; doi:10.1038/s41589-019-0286-6

Rewiring of bacterial two-component systems (TCSs) was achieved by DNA-binding domain swapping of the two largest response regulator families, which enables cross-species porting and provides a tool for identifying ligands for uncharacterized TCSs.
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