Leveraging bias to your advantage

February 20th, 2020 by Sean P. Moran

Nature Chemical Biology, Published online: 20 February 2020; doi:10.1038/s41589-020-0468-2

Characterization of biased receptor signaling has ushered in opportunities for unprecedented control of G-protein-coupled receptors. Elucidation of distinct M1 muscarinic acetylcholine receptor signaling pathways and development of biased ligands may offer novel and safer Alzheimer’s disease therapeutics.