Biomolecular condensates amplify mRNA decapping by biasing enzyme conformation

March 25th, 2021 by Ryan W. Tibble

Nature Chemical Biology, Published online: 25 March 2021; doi:10.1038/s41589-021-00774-x

Alterations in the interactions driving phase separation of the mRNA decapping complex led to conformational rearrangements in its active site, providing a mechanism to control whether substrate mRNA is stored or decapped in condensates.
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