Drug antagonism and single-agent dominance result from differences in death kinetics

April 6th, 2020 by Ryan Richards

Nature Chemical Biology, Published online: 06 April 2020; doi:10.1038/s41589-020-0510-4

Drug combinations consisting of two cell death-targeting drugs are enriched for antagonism and ‘single-agent dominance’, where the faster-acting drug suppresses the slower-acting drug due to inhibitory crosstalk between cell death pathways.
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