Genome-wide screens uncover KDM2B as a modifier of protein binding to heparan sulfate

April 12th, 2021 by Ryan J. Weiss

Nature Chemical Biology, Published online: 12 April 2021; doi:10.1038/s41589-021-00776-9

A CRISPR–Cas9 screen combined with heparan sulfate (HS)-binding reagents identifies genes involved in HS biosynthesis and assembly and reveals the unexpected role of histone demethylase KDM2B in regulating HS presentation on the cell surface.
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