Monobactam formation in sulfazecin by a nonribosomal peptide synthetase thioesterase
November 20th, 2017 by Ryan A Oliver
Monobactam formation in sulfazecin by a nonribosomal peptide synthetase thioesterase
Monobactam formation in sulfazecin by a nonribosomal peptide synthetase thioesterase, Published online: 20 November 2017; doi:10.1038/nchembio.2526
Biosynthesis of the antibiotic sulfazecin involves N-sulfonation in trans of the tripeptide intermediate before synthesis of the β-lactam ring by a noncanonical thioesterase domain, demonstrating a new enzymatic route to the azetidinone moiety.