Structure and functional reselection of the Mango-III fluorogenic RNA aptamer

April 15th, 2019 by Robert J. Trachman III

Structure and functional reselection of the Mango-III fluorogenic RNA aptamer

Structure and functional reselection of the Mango-III fluorogenic RNA aptamer, Published online: 15 April 2019; doi:10.1038/s41589-019-0267-9

Structural analysis of Mango-III in complex with fluorophores reveals a globular architecture and a planar conformation of fluorophores. Structure-guided mutation and functional reselection identified two mutants with improved fluorescence intensity.
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