Biased modulators of NMDA receptors control channel opening and ion selectivity

January 20th, 2020 by Riley E. Perszyk

Nature Chemical Biology, Published online: 20 January 2020; doi:10.1038/s41589-019-0449-5

A series of positive allosteric modulators of NMDA receptors that can increase agonist potency, increase channel-open probability, and slow receptor deactivation can also decrease single-channel conductance and decrease calcium permeability.
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