Chemical libraries: How dark is HTS dark matter?

October 19th, 2015 by Ricardo Macarron

Nature Chemical Biology 11, 904 (2015). doi:10.1038/nchembio.1937

Author: Ricardo Macarron

Selecting compounds for the chemical library is the foundation of high-throughput screening (HTS). After some years and multiple HTS campaigns, many molecules in the Novartis and NIH Molecular Libraries Program screening collections have never been found to be active. An in-depth exploration of the bioactivity of this 'dark matter' does in fact reveal some compounds of interest.