TRUPATH, an open-source biosensor platform for interrogating the GPCR transducerome

May 4th, 2020 by Reid H. J. Olsen

Nature Chemical Biology, Published online: 04 May 2020; doi:10.1038/s41589-020-0535-8

Development of BRET sensors for nearly all major G proteins show that GPCR–G-protein coupling ranges from promiscuous to extremely specific, Switch III is a novel site for G-protein engineering, and optimal donor–acceptor positioning is non-obvious.
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