MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition

May 13th, 2019 by Rebecca C. Coll

MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition

Nature Chemical Biology, Published online: 13 May 2019; doi:10.1038/s41589-019-0277-7

MCC950, a small-molecule inhibitor of the NLRP3 inflammasome, interacts directly with NLRP3 at the Walker B motif that hydrolyzes ATP, as defined by a protease-susceptibility assay, mutational analysis, and surface plasmon resonance analysis.
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