Corrigendum: Protein degradation: Prime time for PROTACs

October 20th, 2015 by Raymond J Deshaies

Nature Chemical Biology 11, 887 (2015). doi:10.1038/nchembio1115-887b

Author: Raymond J Deshaies

Protein degradation: Prime time for PROTACs

August 18th, 2015 by Raymond J Deshaies

Nature Chemical Biology 11, 634 (2015). doi:10.1038/nchembio.1887

Author: Raymond J Deshaies

PROTACs are heterobifunctional small molecules that simultaneously bind a target protein and a ubiquitin ligase, enabling ubiquitination and degradation of the target. Major progress in developing potent and specific PROTACs has recently been reported, invigorating prospects for novel PROTAC-based therapies.