Tailor-made GPCRs

December 16th, 2019 by R. Scott Prosser

Nature Chemical Biology, Published online: 16 December 2019; doi:10.1038/s41589-019-0427-y

An in silico directed evolution approach using first principles of allostery predicts the effects of protein sequence and structure variation on constitutive activity and ligand response in GPCRs.