An essential role of SUMO-specific protease 2 in myostatin expression and myogenesis [Gene Regulation]

December 16th, 2013 by Qi, Y., Zuo, Y., Yeh, E. T. H., Cheng, J.

Sentrin/SUMO-specific protease 2 (SENP2) has broad de-SUMOylation activities in vitro and that it is essential for embryonic heart development. Here, we show that myostatin, a key factor in skeletal muscle development, is markedly reduced in Senp2-/- mouse embryonic fibroblast (MEF) cells and in embryos. SENP2 regulates the transcription of myostatin mainly through de-SUMOylation of MEF2A. Silencing SENP2 can reduce myostatin expression and therefore promote myogenesis of skeletal muscle. These results reveal the important role of SENP2 in the regulation of myostatin expression and myogenesis.