Signaling: Spatial regulation of axonal cAMP
March 22nd, 2017 by Pierre Vincent
Nature Chemical Biology 13, 348 (2017). doi:10.1038/nchembio.2339
Authors: Pierre Vincent & Liliana R Castro
In early-stage developing neurons, the cAMP–PKA (protein kinase A) signaling pathway is strongly inhibited. This negative control is later removed, unleashing cAMP–PKA signaling, particularly in distal axonal parts, thus allowing for axonal growth.