A new target for thalidomide

September 17th, 2018 by Peter G. Wells

A new target for thalidomide

A new target for thalidomide, Published online: 17 September 2018; doi:10.1038/s41589-018-0134-0

One mechanism of thalidomide teratogenicity involves binding to the CUL4–CRBN E3 ubiquitin ligase complex, which then mediates the degradation of transcription factors. New studies reveal that species-specific variants of the transcription factor SALL4 are differentially ubiquitinated and degraded via the thalidomide-bound complex.