Peroxisome compartmentalization of a toxic enzyme improves alkaloid production

October 12th, 2020 by Parbir S. Grewal

Nature Chemical Biology, Published online: 12 October 2020; doi:10.1038/s41589-020-00668-4

Increased production of (S)-reticuline and other alkaloids is achieved through alleviating norcoclaurine synthase toxicity by targeting the enzyme to the peroxisome plus enlarging peroxisomes by expression of engineered transcription factors.
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