Serine is a new target residue for endogenous ADP-ribosylation on histones

October 10th, 2016 by Orsolya Leidecker

Nature Chemical Biology 12, 998 (2016). doi:10.1038/nchembio.2180

Authors: Orsolya Leidecker, Juan José Bonfiglio, Thomas Colby, Qi Zhang, Ilian Atanassov, Roko Zaja, Luca Palazzo, Anna Stockum, Ivan Ahel & Ivan Matic

ADP-ribosylation (ADPr) is a biologically and clinically important post-translational modification, but little is known about the amino acids it targets on cellular proteins. Here we present a proteomic approach for direct in vivo identification and quantification of ADPr sites on histones. We have identified 12 unique ADPr sites in human osteosarcoma cells and report serine ADPr as a new type of histone mark that responds to DNA damage.

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