Prdm4 induction by the small molecule butein promotes white adipose tissue browning

May 9th, 2016 by No-Joon Song

Nature Chemical Biology 12, 479 (2016). doi:10.1038/nchembio.2081

Authors: No-Joon Song, Seri Choi, Prashant Rajbhandari, Seo-Hyuk Chang, Suji Kim, Laurent Vergnes, So-Mi Kwon, Jung-Hoon Yoon, Sukchan Lee, Jin-Mo Ku, Jeong-Soo Lee, Karen Reue, Seung-Hoi Koo, Peter Tontonoz & Kye Won Park

Increasing the thermogenic activity of adipocytes holds promise as an approach to combating human obesity and related metabolic diseases. We identified induction of mouse PR domain containing 4 (Prdm4) by the small molecule butein as a means to induce expression of uncoupling protein 1 (Ucp1), increase energy expenditure, and stimulate the generation of thermogenic adipocytes. This study highlights a Prdm4-dependent pathway, modulated by small molecules, that stimulates browning of white adipose tissue.

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