MYPT1 <i>O</i>-GlcNAc modification regulates sphingosine-1-phosphate mediated contraction

September 14th, 2020 by Nichole J. Pedowitz

Nature Chemical Biology, Published online: 14 September 2020; doi:10.1038/s41589-020-0640-8

Changes in O-GlcNAc levels controlled the actin contraction of fibroblasts in response to sphingosine-1-phosphate (S1P). Specifically, O-GlcNAc modification of the phosphatase MYPT1 maintains its activity to block S1P signaling.
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