Structural and mechanistic insights into 5-lipoxygenase inhibition by natural products

May 11th, 2020 by Nathaniel C. Gilbert

Nature Chemical Biology, Published online: 11 May 2020; doi:10.1038/s41589-020-0544-7

Structures of 5-lipoxygenase (5-LOX) reveal that NDGA disturbs regions that shield the active site while AKBA binds an allosteric site. NDGA inhibits 5-LOX activity using its redox-active function, while AKBA changes the enzyme’s regiospecificity
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