CPSF3-dependent pre-mRNA processing as a druggable node in AML and Ewing’s sarcoma

December 9th, 2019 by Nathan T. Ross

Nature Chemical Biology, Published online: 09 December 2019; doi:10.1038/s41589-019-0424-1

The RNA endonuclease CPSF3 was identified as the cellular efficacy target of the small molecule JTE-607, revealing pre-mRNA processing as a vulnerability in cancers such as Ewing’s sarcoma that are characterized by aberrant transcription.
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