CPSF3-dependent pre-mRNA processing as a druggable node in AML and Ewing’s sarcoma
December 9th, 2019 by Nathan T. Ross
Nature Chemical Biology, Published online: 09 December 2019; doi:10.1038/s41589-019-0424-1
The RNA endonuclease CPSF3 was identified as the cellular efficacy target of the small molecule JTE-607, revealing pre-mRNA processing as a vulnerability in cancers such as Ewing’s sarcoma that are characterized by aberrant transcription.