Selective and reversible modification of kinase cysteines with chlorofluoroacetamides
January 14th, 2019 by Naoya Shindo
Selective and reversible modification of kinase cysteines with chlorofluoroacetamides
Selective and reversible modification of kinase cysteines with chlorofluoroacetamides, Published online: 14 January 2019; doi:10.1038/s41589-018-0204-3
Discovery and exploitation of inherent reaction features of chlorofluoroacetamide (CFA) as a warhead such as low off-target activity and reversible reactivity with cysteine enable specific covalent inhibition of targeted kinases.