Selective and reversible modification of kinase cysteines with chlorofluoroacetamides

January 14th, 2019 by Naoya Shindo

Selective and reversible modification of kinase cysteines with chlorofluoroacetamides

Selective and reversible modification of kinase cysteines with chlorofluoroacetamides, Published online: 14 January 2019; doi:10.1038/s41589-018-0204-3

Discovery and exploitation of inherent reaction features of chlorofluoroacetamide (CFA) as a warhead such as low off-target activity and reversible reactivity with cysteine enable specific covalent inhibition of targeted kinases.
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