APP metabolites AICD, A{beta}42 and Tau in nuclear roles [Gene Regulation]

August 21st, 2015 by Multhaup, G., Huber, O., Buee, L., Galas, M.-C.

APP metabolites (Aβ peptides) and Tau are the main components of senile plaques and neurofibrillary tangles, the two histopathological hallmarks of Alzheimer disease (AD). Consequently, intense research has focused upon deciphering their physiological roles to understand their altered state in AD pathophysiology. Recently, the impact of APP metabolites (AICD, Aβ) and Tau on the nucleus has emerged as an important, new topic. Here we discuss (i) how AICD, Aβ, and Tau reach the nucleus and control protein expression at the transcriptional level, (ii) post-translational modifications of AICD, Aβ, and Tau, and (iii) what these three molecules have in common.