Evolution of chalcone isomerase from a noncatalytic ancestor

April 23rd, 2018 by Miriam Kaltenbach

Evolution of chalcone isomerase from a noncatalytic ancestor

Evolution of chalcone isomerase from a noncatalytic ancestor, Published online: 23 April 2018; doi:10.1038/s41589-018-0042-3

Ancestral sequence inference, directed evolution, structural analysis, NMR, and molecular dynamics simulations illuminate how enantioselective activity arises during the evolutionary trajectory of chalcone isomerase from a noncatalytic ancestor.