Small-molecule control of antibody N-glycosylation in engineered mammalian cells

May 20th, 2019 by Michelle M. Chang

Nature Chemical Biology, Published online: 20 May 2019; doi:10.1038/s41589-019-0288-4

Synthetic gene circuits regulated by small molecules have been used to fine-tune glycosyltransferase expression in CHO cells, providing a method to produce therapeutic monoclonal antibodies with precise glycosylation states.
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