Targeted protein degradation: You can glue it too!

April 13th, 2017 by Michal J Walczak

Nature Chemical Biology 13, 452 (2017). doi:10.1038/nchembio.2355

Authors: Michal J Walczak, Georg Petzold & Nicolas H Thomä

Proteolysis-targeting chimera (PROTACs) are synthetic molecules that recruit neo-substrate proteins to a ubiquitin ligase for ubiquitination and subsequent degradation. Structural insight into the VHL–MZ1–BRD4 complex reveals how the rationally designed MZ1–PROTAC molecule mediates degradation of an unnatural protein substrate.