The origin of genomic <i>N</i><sup>6</sup>-methyl-deoxyadenosine in mammalian cells

March 23rd, 2020 by Michael U. Musheev

Nature Chemical Biology, Published online: 23 March 2020; doi:10.1038/s41589-020-0504-2

A metabolic labeling method reveals that genomic N6-methyl-deoxyadenosine in mammalian cell lines originates not from direct methylation in DNA, but from a misincorporation of the metabolite of ribo-N6-methyladenosine.
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