FINO<sub>2</sub> initiates ferroptosis through GPX4 inactivation and iron oxidation

April 2nd, 2018 by Michael M. Gaschler

FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation

FINO<sub>2</sub> initiates ferroptosis through GPX4 inactivation and iron oxidation, Published online: 02 April 2018; doi:10.1038/s41589-018-0031-6

FINO2 is a small molecule that requires the endoperoxide moiety and hydroxyl group to promote ferroptosis through indirect inhibition of GPX4 enzymatic function and direct oxidation of iron, resulting in increased lipid peroxidation.
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