Processing for destruction

December 9th, 2019 by Michael A. Erb

Nature Chemical Biology, Published online: 09 December 2019; doi:10.1038/s41589-019-0428-x

Phenotypic screening is an engine of discovery for bioactive small molecules and can unravel novel mechanisms and pathways controlling cellular physiology. A recent study reveals the CPSF complex as a pharmacologically tractable target of JTE-607 and context-specific cancer dependency.