Specificity for latent C termini links the E3 ubiquitin ligase CHIP to caspases
July 18th, 2019 by Matthew Ravalin
Nature Chemical Biology, Published online: 18 July 2019; doi:10.1038/s41589-019-0322-6
The C termini sequences recognized by E3 ubiquitin ligase CHIP were identified via a peptide library screen. Caspase cleavage caused the exposure of aspartic acid at the C termini of Tau and caspase-6 that made them accessible to CHIP.