Specificity for latent C termini links the E3 ubiquitin ligase CHIP to caspases

July 18th, 2019 by Matthew Ravalin

Nature Chemical Biology, Published online: 18 July 2019; doi:10.1038/s41589-019-0322-6

The C termini sequences recognized by E3 ubiquitin ligase CHIP were identified via a peptide library screen. Caspase cleavage caused the exposure of aspartic acid at the C termini of Tau and caspase-6 that made them accessible to CHIP.
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